November 19, 2012
These maps represent how people and parasites moved in this study. The red areas represent areas with more movement out of them; blue represents areas with more movement to them; yellow represents areas with equal movement in and out. The map of Kenya on the left depicts human movement, with equal travel to and from several areas. On the right, mosquito parasite movement clearly flows out of the Lake Victoria region (large red patch) and into the Nairobi area (large blue patch). Image courtesy of Caroline Buckee, Harvard University.
A team led by Amy Wesolowski of Carnegie Mellon University in Pittsburgh found that although travelers moved frequently among cities, only some of them were likely to bring malaria along for the ride. The scientists reported their findings Oct. 12 in Science.
The researchers tracked anonymous data from 15 million mobile phone users in Kenya between June 2008 and June 2009. They overlaid the daily movements of subscribers onto detailed maps of known cases of malaria. This yielded estimates of how far and how often the human travelers spread the parasites.
Before this, it was difficult to track how the malaria parasite moved among populated regions. Researchers have relied on crude estimates based on road networks and census data.
Top: The Anopheles funestus mosquito is one of the two most important malaria vectors in Africa. More than 80% of the world's deaths from malaria occur there. Image courtesy of Centers for Disease Control/James Gathany and Dr. Frank Collins/University of Notre Dame. Bottom: A crowded bus in Nairobi, Kenya. Image courtesy of Alex Kamweru.
Public-health workers have mostly succeeded in wiping out malaria in Kenya's capital, Nairobi. However, the disease continues to pop up in the crowded city. The new study suggests the parasites are like marbles rolling downhill from the high-malaria Lake Victoria region to otherwise malaria-free Nairobi, and will continue to do so until the source of the disease is eliminated in Lake Victoria.
"It's very clear that the parasites are coming from Lake Victoria and ending up on the periphery of that region and in the capital," said Buckee.
The researchers also used the high density of cell phone towers in Nairobi to answer a contentious question: Does malaria spread within the city itself? The results showed little evidence of transmission in the center of the city, but there are signs malaria does migrate around the periphery. "So there would be a good place to start looking for pockets of transmission," Buckee said.
Map of Kenya with major geographic landmarks. Courtesy of wordtravels.com, creative commons license.
Still, the technique has unveiled worthy data, other scientists say. "What a novel notion to use mobile phone data to track disease—still imprecisely, but provocatively," William Shaffner, who heads the Preventive Medicine Department at Vanderbilt University Medical Center in Nashville, Tenn., told mongabay.com.
The new method can pinpoint hot spots and direct public health efforts, he noted. "You can now rifle your interventions instead of shot-gunning them. It gives you the potential to direct your limited resources," Shaffner said.
CITATION: CITATION: Amy Wesolowski, Nathan Eagle, Andrew J. Tatem, David L. Smith, Abdisalan M. Noor, Robert W. Snow, Caroline O. Buckee. Quantifying the Impact of Human Mobility on Malaria, Science, 12 October 2012 DOI: 10.1126/science.1223467.
Rina Shaikh-Lesko, a former epidemiologist, is a graduate student in the Science Communication Program at the University of California, Santa Cruz.
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